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- W2371643860 abstract "Objective To investigate the protective effects of 1-hydroxy-2, 3, 5-trimethoxyxanthone (QGS) on acute lung injury of mice induced by ip lipopolysaccharide (LPS). Methods Mice were pretreated with QGS for 7 d. Murine models of acute lung injury were duplicated by injection of LPS 20 mg/kg intraperitoneally. In 12 h, the lung weight index was observed and the NO level in the bronchoalveolar lavage fluid (BALF) was measured with kits. The lung was also assessd for the expression of I-κB, inducible nitric oxide synthase (iNOS), and cyclooxygenase-Ⅱ (COX-2) using Western blotting analysis. Lung pathological changes were also observed by HE in each group. Results The lung weight index of injury lung in mice induced by LPS was decreased in 500 mg/kg QGS group (P0.05), the NO level in BALF of mice induced by LPS was decreased significantly in 250 and 500 mg/kg QGS groups with the inhibitory rate of 37% and 48.1%, respectively. Meanwhile the protein expression of IκB-α in lung tissue was increased remarkably but the expression of iNOS and COX-2 was suppressed in 500 mg/kg QGS group. Conclusion QGS could protect mice from the acute lung injury induced by LPS, which is relative to the increasing of IκB-α protein expression and the suppressing of iNOS and COX-2 protein expression." @default.
- W2371643860 created "2016-06-24" @default.
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- W2371643860 date "2007-01-01" @default.
- W2371643860 modified "2023-09-23" @default.
- W2371643860 title "Protection of 1-hydroxy-2, 3, 5-trimethoxyxanthone on acute lung injury of mice induced by lipopolysaccharide" @default.
- W2371643860 hasPublicationYear "2007" @default.
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