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- W2371661333 abstract "Objective: To obtain B cell lineage cells from the bone marrow of lupus BXSB mice and observe whether there is an interrelation between the Yaa gene and B cell lineage differentiation. Methods: B cell lineage cells were isolated with Whitlock Witte method, and their surface phenotype, proliferation, production of anti DNA antibody after response to lipopolysaccharide (LPS) and apoptosis status induced by dexamethasone were detected. Results:B cell lineage cells derived from male or female BXSB mice had identical distribution of CD19 and surface membrane Ig , proliferative response with similar intensity and produced approximate levels of IgM anti DNA antibodies after LPS stimulation. Besides , the B cell lineage cells were resistant to the Dex induced apoptosis. Conclusion: Yaa gene has no effects on the differentiation and development of the bone marrow B cell lineage cells in SLE BXSB mice, suggesting that its activity only appears in the peripheral mature B cells. The autoactive B cell lineage cells in the bone marrow of BXSB mice are not deleted, which maybe is one of the intrinsic reasons of producing autoantibodies." @default.
- W2371661333 created "2016-06-24" @default.
- W2371661333 creator A5043874743 @default.
- W2371661333 date "2000-01-01" @default.
- W2371661333 modified "2023-09-23" @default.
- W2371661333 title "Study on the differentiation and development of bone marrow B cell lineage cells from systemic lupus erythematosus BXSB mice" @default.
- W2371661333 hasPublicationYear "2000" @default.
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