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- W2371668747 abstract "Objective To investigate the expressions of VEGF-C and CD44v6 in hepatocellular carcinoma(HCC) and their association with biological behavior of the disease. Methods The expressions of VEGF-C and CD44v6 in liver tissue of 33 HCC patients were examined by immunohistochemical staining,and 21 patients with portal hypertension and 16 hepatic-trauma patients served as controls. Results VEGF-C was expressed in cytoplasma in cancer tissues.The positive expression rate of VEGF was 78.8%.The expression of CD44v6 was located in membranes as well as cytoplasma in HCC,expression rate being 72.7%.The expression rates of both VEGF and CD44v6 in HCC were significantly higher than that of the adjacent tissues(χ2=12.157,10.280;P0.05),VEGF and CD44v6 expressions in metastasis were significantly higher than that in the non-metastasis(χ2=4.930,8.088;P0.05).Hardly any expressions of VEGF-C and CD44v6 were noted in normal liver or cirrhotic tissue.The expressions of VEGF-C and CD44v6 had nothing to do with tumor size and grade,AFP level,presence or absence of cirrhosis or HBV.There was a positive correlation between VEGF-C and CD44v6 in HCC(r=0.681,P0.01). Conclusion The expressions of VEGF-C and CD44v6 are correlated with tumor metastasis and invasion,which may be used as an index for estimating the prognosis of HCC." @default.
- W2371668747 created "2016-06-24" @default.
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- W2371668747 date "2009-01-01" @default.
- W2371668747 modified "2023-09-23" @default.
- W2371668747 title "EXPRESSIONS AND SIGNIFICANCE OF VEGF-C AND CD44v6 IN HEPATOCELLULAR CARCINOMA" @default.
- W2371668747 hasPublicationYear "2009" @default.
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