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- W2371699887 abstract "Objective To investigate regional blood flow (RBF) and metabolism changes in the short- and long-term after bone irradiation injury. Methods The tibia of the rabbits on the right side was irradiated with 60 Co γ ray at a dose of 30 Gy. The tibia on the other side was taken as the control. RBF measurement, perfusion imaging and delayed bone imaging were respectively performed at the 1st, 3rd, 6th, 12th, 24th and 52nd week after the irradiation. Results The RBF of injured side gradually increased after irradiation, and reached as two times as the level of the control at the 3rd week, and approached to the similar values on both sides at the 6th week, and then became only 27.8% of the value of the control at the 52nd week, the differences of RBF between two sides at all phases were significant or very significant( P 0.05～0.01). Time-activity curve of perfusion imaging on irradiated side was apparently higher than that on control side at the 3rd week after irradiation and slightly higher at the 6th week, began to decrease at the 12th week and was only about 25% of the value of the control at the 52nd week. The region of interest (ROI) counts of damaged side on delayed bone imaging was obviously increased in comparison with control side at the 3rd week( P 0.01), there was no difference between both sides at the 6th week ( P 0.05), the ROI counts markedly decreased at the 12th week and very significantly declined at the 52nd week on irradiated side. Conclusions The study shows that the RBF increases and bone metabolism is activated at irradiated side in the earlier stage after irradiation, and both regional microcirculation and bone metabolism significantly decrease in the medium and late stage." @default.
- W2371699887 created "2016-06-24" @default.
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- W2371699887 date "2002-01-01" @default.
- W2371699887 modified "2023-09-28" @default.
- W2371699887 title "Experimental studies of blood flow and metabolism changes in γ-ray induced bone injury" @default.
- W2371699887 hasPublicationYear "2002" @default.
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