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- W2371700845 abstract "Objective To detect the prevalence of myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) in patients with polymyositis (PM) and dermatomyositis (DM), and analyse the correlation between MSAs and the clinical features and prognosis of PM/DM. Methods Serum samples of 31 PM and DM patients were screened for MSAs (including anti Jo-1, anti Mi-2, anti PL-7, anti PL-12 antibodies) and MAAs (including anti Ku, anti PM-Scl antibodies) by immunoblotting test. Results Serum MSAs/MAAs were detected in 18 out of 31 PM/DM patients (58%). MSAs were present in 12 patients (39%). The most frequently encountered MSAs was anti-Jo-1 autoantibody (29%), followed by anti-Mi-2 (7%), anti-PL-7 (3%), and anti-PL-12 (3%). MAAs were present in 10 patients (32%), including anti-Ku-72 (16%), anti-Ku-86 (23%) and anti-PM/Scl (7%). Notably, anti-Jo-1 antibody was closely associated with interstitial lung disease (ILD) and arthritis/arthralgia compared with the anti-Jo-1 antibody negative patients (P0.05). Treatment of corticosteroid plus immunosuppressive drugs was effective in achieving complete remission in 18 patients and partial remission in 12 patients, but relapse was frequent during follow-up (1~12 years). The relapse frequency and mortality were similar between MSAs positive and negative groups. The incidence of ILD was significantly increased in MSAs positive patients with a poor prognosis. Conclusions Our data indicate that the prevalence of MSAs and MAAs are high in PM/DM patients. MSAs are associated with clinical features and prognosis in patients with PM and DM. The determination of MSAs/MAAs has important implication for clinical diagnosis and treatment of PM and DM." @default.
- W2371700845 created "2016-06-24" @default.
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- W2371700845 date "2005-01-01" @default.
- W2371700845 modified "2023-09-24" @default.
- W2371700845 title "The clinical significance of myositis specific autoantibodies in polymyositis and dermatomyositis" @default.
- W2371700845 hasPublicationYear "2005" @default.
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