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- W2371710483 abstract "Objectives To investigate the effect of tumor necrosis factor α on skeletal muscle ischemia reperfusion injury (SMIR). Methods Twenty four healthy male Sprague Dawley rats were divided into three groups. Group A underwent anesthesia and external jugular vein cannulation only. Group B underwent 4 hours of left hind limb ischemia followed by 4 hour reperfusion. Group C ischemia and reperfusion were treated with anti TNF α monoclonal antibody (2?mg/kg). ResultsSMIR significantly increased the transcription of TNF α mRNA in monocyte. The increased TNF α raised significantly the level of MDA(9 9±1 8 vs. 5 5±0 4)?CK(122±24 vs. 49±11)?NO(270±98 vs. 128±46) in plasma and MPO(skeletal muscle 4 27±0 53 vs. 1 28±0 19, lung 2 61± 0 12 vs. 0 57±0 02) in tissues respectively( P 0 01), and consequently resulted in ultrastructural injury in both skeletal muscle and the lung.Anti TNF α monoclonal antibody decreses the level of MDA( 6 2± 1 2 vs. 9 9± 1 8)?CK(58±12 vs. 122±24)?NO(154±55 vs. 270±98)and MPO(skeletal muscle 2 13± 0 21 vs. 4 27± 0 53, lung 0 95±0 01 vs. 2 61±0 12) ( P 0 05)and alleviates the pathological injuries in skeletal muscle and the lung. ConclusionsSMIR enhanced the synthesis of TNF α, which induces the injury of skeletal muscle and the lung." @default.
- W2371710483 created "2016-06-24" @default.
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- W2371710483 date "2002-01-01" @default.
- W2371710483 modified "2023-09-23" @default.
- W2371710483 title "Effects of tumor necrosis factor-α on skeletal muscle ischemia reperfusion injury" @default.
- W2371710483 hasPublicationYear "2002" @default.
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