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- W2371722756 abstract "Objective: To investigate the expressions of STAT3(signal transducers and activators of transcription 3) and c-myc gene in hepatocellular carcinoma SMMC-7721 cells,observe the effects of antibody interference on cell proliferation and apoptosis,and analyze the correlation of the two genes.Methods: The protein and mRNA expressions of STAT3 and c-myc in SMMC-7721 cells were detected by immunocytochemical method and semi-quantitative RT-PCR,respectively.After antibody interference,cell proliferation was assessed by MTT assay;apoptosis was detected by flow cytometry;the mRNA expressions of STAT3 and c-myc were determined by RT-PCR.Results: Both STAT3 and c-myc were expressed in hepatocellular carcinoma SMMC-7721 cells.Immunocytochemical analysis showed that STAT3 and c-myc proteins were mainly localized in the cytoplasm.Proliferation and apoptosis of SMMC-7721 cells were inhi-bited by treatment with anti-STAT3 antibody and anti-c-myc antibody alone or in combination.The inhibitory effect was more significant for combined therapy group at 48 h.RT-PCR demonstrated that c-myc mRNA expression had significantly decreased after treatment with anti-STAT3 antibody alone and it further decreased after combined treatment.Conclusion:Our findings demonstrated that STAT3 and c-myc signaling pathway exists in SMMC-7721 cell line.STAT3 inhibites the apoptosis and facilitates the proliferation of SMMC-7721 cells by up-regulating c-myc expression.STAT3 and c-myc play a critical role in the initiation and progression of hepatocellular carcinoma." @default.
- W2371722756 created "2016-06-24" @default.
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- W2371722756 date "2008-01-01" @default.
- W2371722756 modified "2023-09-22" @default.
- W2371722756 title "The expressions of STAT3 and c-myc in hepatocellular carcinoma and their significance" @default.
- W2371722756 hasPublicationYear "2008" @default.
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