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- W2371734306 abstract "objective: To accurately determine the anti-mutation effects of the aqueous extract of five tonic traditional Chinese medicinal herbs [Gynostemma pentaphyllum,Glycyrrhiza uralensis Fisch,Ginseng(Panax ginseng),Astragalus membranaceus and Fructus ligustri] and to determine the dose effect of each.Methods: The world-wide adopted means(micronucleus test of polychromatic erythrocyte in mouse bone marrow cells,chromosomal aberration test of mouse bone marrow cells,Ames test,sister chromatid exchanges test in the lymphocytes of human blood,micronucleus test in the lymphocytes of human blood,chromosomal aberration test of CHO cells) were used to systematically study the anti-mutation effects of the above five traditional Chinese medicines under different doses.Results: Medium to high dose groups for Ginseng,G.pentaphyllum and A.membranaceus and all three dose groups for G.uralensis Fisch decreased CP-induced micronucleus frequency in mouse bone marrow cells(p0.05).All three dose groups for G.pentaphyllum and G.uralensis Fisch,the high dose group for Ginseng and the median and high dose groups for G.uralensis Fisch showed inhibition effectiveness to the increase in CP-induced chromosomal aberration ratio of mouse bone marrow cells(p0.05).All three dose groups for Ginseng,G.uralensis Fisch and G.pentaphyllum restrained the increase in the back matagenesis of TA98 induced by 2,7-AF(p0.05).For A.membranaceus,however,only the high dose group was effective(p0.05).All three dose groups for A.membranaceus and F.ligustri and high dose group for G.pentaphyllum inhibited the increase in back matagenesis of TA100 induced by NaN3(p0.05).High dose group for G.pentaphyllum and median dose group for G.pentaphyllum inhibited the increase inf SCE in the lymphocytes of human blood induced by MMC(p0.05).High dose group for Ginseng,three dose groups for G.pentaphyllum and low and median groups for F.ligustri inhibited the increase in MN in the lymphocytes of human blood induced by MMC(p0.05).High dose group for ginseng,three dose groups for G.pentaphyllum and G.uralensis Fisch,and high dose groups for G.pentaphyllum and G.uralensis Fisch inhibited chromosomal aberration of CHO cells induced by MMC(p0.05).Conclusions: G.pentaphyllum,G.uralensis Fisch and Ginseng show good anti-mutant activity.Their effective dose ranges are quite wide.A.membranaceus and F.ligustri lucidi showed only limited effectiveness against induced mutation." @default.
- W2371734306 created "2016-06-24" @default.
- W2371734306 creator A5076930880 @default.
- W2371734306 date "2009-01-01" @default.
- W2371734306 modified "2023-09-24" @default.
- W2371734306 title "A Comparative Experiment on Anti-mutation Effects of Five Tonic Traditional Chinese Medicinal Herbs" @default.
- W2371734306 hasPublicationYear "2009" @default.
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