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- W2371736720 abstract "Objectives To investigate the distribution of CD14 promoter gene-C-159T polymorphism in Guangdong Han population of China and analyze the association of CD14 polymorphisms with juvenile idiopathic arthritis(JIA).Methods Genotypes of CD14 were determined in 104 JIA patients and 281 controls by polymerase chain reaction-restriction fragment length polymorphism.Results CD14 promoter-159 genotype frequencies of CC,CT and TT in systemic JIA group were 10.87%,41.30%,47.83%;and 12.50%、 50.00%、 37.50% in polyarticular JIA group;and 10.00%、 65.00%、 25.00% in oligoarticular JIA;and 7.14% 、 71.43% 、 21.43% in other JIA;and in normal control group were 37.01%、 46.98%、 16.01%.Genotype distribution was in accordance with Hardy-Weinberg equilibrium.There existed statistically significant difference in frequencies of genotype and allele in CD14 C-159T polymorphism between systemic JIA group and control group,Polyarticular JIA group and control group.There also existed statistically difference in frequencies of allele between oligoarticular JIA group and control group.The T allele frequency of male and female were significantly higher than those in the control group(P 0.001 of both).Conclusions There existed statistically significant correlation of CD14 gene promoter region-159 polymorphism with systemic JIA and polyarticular JIA among Han population in Guangdong;The T allele of the C-159T polymorphism of CD14 gene may be a risk factor for juvenile idiopathic arthritis in Han population." @default.
- W2371736720 created "2016-06-24" @default.
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- W2371736720 date "2009-01-01" @default.
- W2371736720 modified "2023-09-23" @default.
- W2371736720 title "Study on the association between C159-T polymorphism in promoter region of CD14 and juvenile idiopathic arthritis" @default.
- W2371736720 hasPublicationYear "2009" @default.
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