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- W2371738455 abstract "Objective To explore the mechanism of action of preserved amniotic membrane to inhibit neovascularization and inflammation after corneal alkaline burn.Methods A total of 160 healthy mice were burned the right eyes with NaOH and divided into conventional treatment group(group A)and conventional treatment combined with amniotic membrane transplantation group(group B)randomly.The expression of vascular endothelial growth factor(VEGF),pigment epithelium derived factor(PEDF)and nuclear factor-κB(NF-κB)was detected on the 3rd,7th,10th and 14th day respectively by immunohistochemical SP method.Results 1.On the 3rd day and 7th day,expression of VEGF and NF-KB decreased in group B compared to A(all P0.05).On the 10th and 14th day,expression of VEGF and NF-κB was no statistical difference in group A and group B(P0.05).2.Expression of PEDF on the 3rd,7th,10th and 14th day in group B increased not remarkably compared to group A(P0.05).4.There was positive correlation between the expression of NF-κB and VEGF in group A and B.Conclusion 1.Amniotic membrane transplantation maybe resist neovascularization and inflammation by inhibiting the expression of NF-κB and VEGF.2.Amniotic membrane transplantation can not increase the expression of PEDF in the corneal tissue." @default.
- W2371738455 created "2016-06-24" @default.
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- W2371738455 date "2009-01-01" @default.
- W2371738455 modified "2023-09-26" @default.
- W2371738455 title "Expression of VEGF,PEDF and NF-κB in corneal after amniotic membrane transplantation for alkaline burn" @default.
- W2371738455 hasPublicationYear "2009" @default.
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