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- W2371746286 abstract "Objective: To detect the expression of microvessel density (MVD) and transcription factor Ets1 in breast intra-ductal proliferative lesion and infiltrating ductal carcinoma. Methods: Immunohistochemistry and computer-assisted image analysis system were used to detect the expression of MVD and transcription factor Ets1 and the downstream protein MMP1 in 152 routinely paraffin embedded specimens which included 18 cases of normal breast (NB group),20 cases of usual ductal hy-perplasia (UDH group),29 cases of atypical ductal hyperplasia (ADH group),15 cases of ductal carcinoma in situ(DCIS group),and 70 cases of infiltrating ductal carcinoma (IDC group). Results: MVD showed an increasing trend from normal breast to infiltrating ductal carcinoma,and a significant increase was showed in IDC group. The positive expression of Ets1 and MMP1 was increased according to the degree of the hyperplasia of breast intraductal epithelium, and in IDC group exhibited a significantly increased immunoreactivity compared with intraductal proliferative lesion (P 0.01). In IDC group, Ets1 signifi-cantly correlated with MMP1 (r = 0.55, P 0.01). Ets1 and MMP1 were all significantly correlated with MVD marked by CD34 (r = 0.57, r = 0.60, and respectively, P 0.01). Conclusion: Ets1 may play an important role in regulating angiogenesis in breast cancer." @default.
- W2371746286 created "2016-06-24" @default.
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- W2371746286 date "2009-01-01" @default.
- W2371746286 modified "2023-09-23" @default.
- W2371746286 title "Relationship between Tumor Angiogenesis and Transcription Factor Ets1 in Breast Infiltrating Ductal Carcinoma" @default.
- W2371746286 hasPublicationYear "2009" @default.
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