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- W2371750765 abstract "Bovine mammary epithelial cells were exposed to 40 ℃ for 1 hour or successive 40 ℃ 1 h·d-1(3-7 d)to study the effects of hyperthermia on cell cycle,apoptosis and heat shock protein(HSP70)expression,by low cytometry,trypan blue dying,and immunohistochemistry.The results showed as follows:the percent of G2 phase of heat treatment group at 24 hour after hyperthermia was significantly higher than the 37 ℃ control(P0.01),and apoptosis rate was the highest at 6 hour after heat treatment.Hyperthermia induced HSP70 expression,and the rate of HSP70 positive expression cells maximized at the 3 hour after heat treatment.Successive 40 ℃ 1 h·d-1 heat treatment induced cell cycle block at G2 phase.The cell numbers of heat-treated group(treated for more than 4 days)were significant lower than those in 37 ℃ control group(P0.05).It is suggested that hyperthermia induces cell cycle arrest,apoptosis and HSP70 expression." @default.
- W2371750765 created "2016-06-24" @default.
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- W2371750765 date "2007-01-01" @default.
- W2371750765 modified "2023-09-23" @default.
- W2371750765 title "Effects of unitary or successive heat treatment on mammary epithelial cells proliferation and apoptosis" @default.
- W2371750765 hasPublicationYear "2007" @default.
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