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- W2371777589 abstract "OBJECTIVE To study the pharmacokinetics of hydroxysafflor yellow A for intravenous infusion injection in Chinese healthy volunteers.METHODS 12 Healthy volunteers,randomly divided into 3 groups with 4 volunteers in each group, received HSYA at single dose of 35,70 and 140 mg,respectively.The concentrations of HSYA in human plasma at different time were analyzed by HPLC-UV method.The pharmacokinetic parameters were calculated by the software DAS 2.0.RESULTS The plasma concentration-time curves of the preparation were fitted by a two-compartment model.The main pharmacokinetic parameters were as follows:ρ_(max) were(2.02±0.18),(7.42±0.61),(14.48±4.71) mg·L~(-1);t_(l/2β) were(3.05±0.70),(3.56±0.77), (3.35±0.91)h;AUC_(0 15)were(6.79±1.29),(26.75±5.46),(49.81±13.75)mg·h·L~(-1)。AUC_(0-∞) were(7.85±1.07),(28.60±5.51), (53.80±14.85) mg·h·L~(-1).CONCLUSION The t_(1/2β) was similar among three dosages and the values of AUC_(0-15),AUC_(0-∞),ρ_(max) were linear in the dose range from 35 mg to 140 mg." @default.
- W2371777589 created "2016-06-24" @default.
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- W2371777589 date "2009-01-01" @default.
- W2371777589 modified "2023-09-27" @default.
- W2371777589 title "Study on Pharmacokinetics of Hydroxysafflor Yellow A in Chinese Healthy Volunteers" @default.
- W2371777589 hasPublicationYear "2009" @default.
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