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- W2371778265 abstract "Objective To investigate the expression of transforming growth factor-β 1 (TGF-β 1 )and its receptor(TβRⅠ)in the renal tissue of rats with active Heymann nephritis(AHN)and to explore their role in the pathogenesis of AHN.Methods SD rats were immunized with FxlA to induce AHN.AHN and control rats were sacrificed at4?6?8and12weeks.The expression of TGF-β 1 and TβR I in rat renal tissue were detected with SP immunohistochemical technique and were analyzed semi-quantitatively with the computer imaging analysis system.Results At the4th week after the induction of AHN,the expression of TGF-β 1 and TβRⅠin the renal tissue of AHN rats were up-regulated.At the8th week the expression of TGF-β 1 and TβRⅠreached a peak and at the12th week these two factors slightly declined(P0.05).Conclusions The expresˉsion of TGF-β 1 and TβRⅠwere up-regulated in the kidneys of the rats with AHN and TGF-β 1 may play an important role in the pathogenesis of AHN." @default.
- W2371778265 created "2016-06-24" @default.
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- W2371778265 date "2003-01-01" @default.
- W2371778265 modified "2023-09-27" @default.
- W2371778265 title "The role of transforming growth factor-β_1 and its receptor in the pathogenesis of active Heymann nephritis" @default.
- W2371778265 hasPublicationYear "2003" @default.
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