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- W2371781320 abstract "Six healthy volunteers were given po ofloxacin (OFX) 400 mg, the serum drug concentrations were determined by reverse-phase HPLC to study its pharma-cokinetic characteristics. Antimicrobial activities of OFX in vitro to 918 strains isolated from patients were also examined. The results showed that OFX (had excellent antibacterial effect to almost all of Gram-positive and Gram-negative organisms. The inhibition rates were over 90% for most of the strains. After oral administration, the serum concentration-time profile of OFX conformed to the one compartment open model. Tmax and Cmax were 1.3h and 4.4ug/mL, respectively. T1/2ka and T1/2ke were 0.8h and 3.7h, respectively. Cl was 0.36L/(hkg). Vd was 1.9L/kg. These data showed that the drug was widely distributed in the tissue and body fluid." @default.
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- W2371781320 date "1992-01-01" @default.
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- W2371781320 title "Pharmacokinetics of ofloxacin and its antimicrobial activities in vitro" @default.
- W2371781320 hasPublicationYear "1992" @default.
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