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- W2371782545 abstract "Objective To observe the therapeutic effect of synchronous chemoradiation for advanced cervical cancer and evaluate the feasibility of cervical secretion HPV-DNA and serum TNF-α as monitoring indicators on curative effect.Methods Seventy-four patients of advanced cervical cancer were randomly divided into concurrent radiochemotherapy group(n=42) and simple radiotherapy group(n=32).The patients of the simple radiotherapy group were treated with accelerator extracorporeal irradiation and 192Ir intracavitary afterloading therapy,while the patients of the concurrent radiochemotherapy were treated not only with the radiotherapy mentioned above,but also with chemotherapy,which included paclitaxel 50 mg/m2 and cisplatin 40 mg/m2,once a week and a total of 6 weeks.Before and after treatment,the second-generation hybrid capture technology(HC-Ⅱ) and double antibody sandwich enzyme linked immunosorbent assay(ABC-ELISA) were used to detect the cervical secretion HPV-DNA expression and serum TNF-α content,respectively.Results The overall response rate of the concurrent radiochemotherapy(90.5%) was better than that of the simple radiotherapy group(65.6%)(P0.05),and the 5-year survival rate of the first group(59.5%) was also higher than that of the second group(40.0%)(P0.05).Both the myelosuppression rate and gastrointestinal reaction rate of the the concurrent radiochemotherapy were much higher than those of the simple radiotherapy group(P0.05),but should not affect the course of treatment.In both groups,the cervical secretion HPV-DNA positive rate and serum TNF-α levels decreased significantly after therapy(P0.01).Conclusion Concurrent radiochemotherapy can significantly improve the 5-year survival rate of the patients with advanced cervical cancer,and the changes of cervical secretion HPV-DNA expression and serum TNF-α content can be used as monitoring indicators on curative effect." @default.
- W2371782545 created "2016-06-24" @default.
- W2371782545 creator A5088706496 @default.
- W2371782545 date "2011-01-01" @default.
- W2371782545 modified "2023-09-22" @default.
- W2371782545 title "Clinical observation on concurrent radio-chemotherapy for advanced cervical cancer" @default.
- W2371782545 hasPublicationYear "2011" @default.
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