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- W2371793330 abstract "Objective To study the immunoregulation effect of rhIL-18 on irradiated mice.Methods Thirty-two C57 mice were randomly divided into normal control group,irradiated group,rhIL-18+irradiated group,irradiated +rhIL-18 group.The animals were irradiated with 60Co (γ rays 4.0 Gy)and treated with rhIL-18 alternately.After 2 weeks,the lymphocyte transform ability,NK cells cytotoxic activity,T cells subtype were examined,the levels of IL-2,IFN-γ,GM-CSF,and IL-4 in the supernatant of cultured splenocytes in vitro and content of IgG in serum were also tested.Results rhIL-18 could make T and B lymphocyte transform function of 60Co irradiated mice to recover or even better than normal levels (P0.05).The stimulating index (SI) in irradiated +rhIL-18 group reachad to 2.9 (ConA test) and 6.1 (LPS test).rhIL-18 could enhance cytotoxic activity mediated by NK cells against tumor cells of A375,U937 and KG1 cells.The rate of killing tumor cells by NK cells was 21.8 to 35.6%(P0.05).Moreover,rhIL-18 could up-regulate the number of CD4 T cells to 50 cells/ml and improve splenocytes of irradiated mice to secret cytokines of IL-2,IFN-γ,GM-CSF(P0.05) but not IL-4 and IgG.Conclusion rhIL-18 could improve the immune function of irradiated mice." @default.
- W2371793330 created "2016-06-24" @default.
- W2371793330 creator A5043274381 @default.
- W2371793330 date "2010-01-01" @default.
- W2371793330 modified "2023-09-24" @default.
- W2371793330 title "EFFECT OF rhIL-18 ON IMMUNOREGULATION OF MICE WITH RADIATION DAMAGE" @default.
- W2371793330 hasPublicationYear "2010" @default.
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