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- W2371793394 abstract "Objective To observe the effect of edaravone on myocardial infraction size and IL-1β, TNF-αin blood in myocardial ischemia reperfusion injury rats. Methods The rats were divided into five groups : sham operation group,I/ R group,three treatment groups treated with low,middle and high dosage of edaravone . The model of I/ R was induced by ligating the anterior descending branch of the left coronary artery for 30min/ opening for 120min. The effect of edaravone pretreatment on the size of myocardial infarction and the changes of IL-1βand TNF-αin blood were observed. Result The extent of myocardial infarction in groups treated with high and low dosage of edaravone was reduced significantly compared with model group,the percentage of infarcted myocardium weight of the whole heart and left ventricle had significant difference ( P 0.01,0.001),effect of middle dosage edaravone treated group was excellent. IL-1β and TNF-α in blood were down regulated to different degree after giving edaravone,and the effect of high and middle dosage edaravone treated group was excellent ( P 0.01). Conclusion Edaravone could reduce ischemic reperfused myocardium injury caused by IL-1βand TNF-α." @default.
- W2371793394 created "2016-06-24" @default.
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- W2371793394 date "2008-01-01" @default.
- W2371793394 modified "2023-09-27" @default.
- W2371793394 title "Effect of Edaravone Preconditioning on Serum of TNF-α and Interleukin-1β and Myocardial Infarction Zone of Rats with Ischemia Reperfusion Injury (MIRI)" @default.
- W2371793394 hasPublicationYear "2008" @default.
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