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- W2371796319 abstract "Objective To observe the role of paraoxonase-1 and oxidative stress in pathogenesis of insulin resistance in patients with polycystic ovary syndrome (PCOS).Methods 41 PCOS patients divided into obese group and non-obese group with 20 healthy volunteers as a control.The 75g oral glucose tolerance test (OGTT) and insulin releasing test (IRT) were performed.The insulin resistance and β-cell function were estimated with homeostasis model assessment (HOMA).The fasting serum concentration of malondialdehyde (MDA),and the activities of superoxide dismutase (SOD) and paraoxonase-1 (PON-1) were assayed.Results (1)The levels of fasting plasma insulin,2 hour plasma glucose and insulin,the index of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were significantly higher in PCOS patients of both non-obese group and obese group than in healthy controls(all P0.05).HOMA-β was not different between non-obese group and obese group in PCOS patients(P0.05),while the the levels of BMI,2hPG,FIns,2hIns,and HOMA-IR were significantly higher in obese group than in non-obese group(all P0.05).(2)The PCOS patients in both non-obese group and obese group showed higher MDA and lower SOD and PON-1 than in healthy controls(P0.05).The serum concentration of MDA and the activity PON-1 showed no differences between non-obese group and obese group in PCOS patients (both,P0.05),but The activity of SOD was significantly lower in obese group than in non-obese group (P0.01).(3) SOD had a positive correlation with PON-1 (r=0.417,P=0.043),and a negative correlation with HOMA IR(r=-0.492,P=0.015)in non-obese PCOS group.Conclusion The PCOS patients has an increased postprandial plasma glucose,impared PON-1 activity,oxidative stress,insulin resistance,and high level of plasma insulin in non-obese and especially in obese subgroup.Insulin resistance is related to oxidative stress in patients with PCOS." @default.
- W2371796319 created "2016-06-24" @default.
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- W2371796319 date "2011-01-01" @default.
- W2371796319 modified "2023-09-23" @default.
- W2371796319 title "The correlation of serum paraoxonase-l and oxidative stress with insulin resistance in patients with polycystic ovary syndrome" @default.
- W2371796319 hasPublicationYear "2011" @default.
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