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- W2371796747 abstract "Objective To study the relationship between the expression of p57KIP2 and clinicopathological characteristics in invasive duct carcinoma(IDC).Methods In 64 cases of IDC,15 cases of ductal carcinoma in situ(DCIS),15 cases of benign breast tissue and 15 cases of adjacent normal breast tissues,the expression of p57KIP2 proteins was detected by immunohistochemical S-P methods.Results In 64 cases of IDC,15 cases of DCIS,15 cases of benign breast diseases and 15 cases of normal breast tissues,the positive expression rate of p57KIP2 were 34.38%(22/64)、66.67%(10/15)、80.00%(12/15)、86.67%(13/15) respectively.The expression of p57KIP2 between IDC and DCIS,IDC and benign breast diseases,IDC and normal breast tissues had significant difference(P0.01).In IDC,the positive expression of p57KIP2 was correlated with axilliaris lymph node metastasis(P0.01),but was no correlation with the number of lymph node metastasis,histological grade,age and tumor diameter(P0.05).Conclusions This investigation show that p57KIP2 gene may play an important role in the mammary tissue carcinogenesis and progression of breast carcinoma.The decreased expression of p57KIP2 protein might be important biological marker for malignant transformation of breast tissue and lymph node metastasis of breast carcinoma." @default.
- W2371796747 created "2016-06-24" @default.
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- W2371796747 date "2007-01-01" @default.
- W2371796747 modified "2023-09-25" @default.
- W2371796747 title "Relationship between the expression of p57~(KIP2) and its clinicopathological characteristics in invasive duct carcinoma of the breast" @default.
- W2371796747 hasPublicationYear "2007" @default.
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