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- W2371804889 abstract "Objective To observe the effects of the over-expressions of ASPP1 and ASPP2 on the apoptosis ability in resveratrol-induced MCF-7 breast cancer cells.Methods pcDNA3/ASPP1 and pcDNA3/ASPP2 were transfected into MCF-7cells by Fugen-6.Positive clone cells MCF-7/ASPP1and MCF-7/ASPP2 were obtained by persistent G418 selection.MCF-7,MCF-7/ASPP1 and MCF-7/ASPP2 cells were treated with 0,25 and 50μmol/L resveratrol,respectively,and were detected apoptosis cells by using MTT assay.RT-PCR was applied to detect the expression of apoptosis associated protein as Bax and p21mRNA.MCF-7,MCF-7/ASPP1 and MCF-7/ASPP2 cells were treated with0,100 and 200μmol/L resveratrol,respectively,and were detected the apoptosis rates by using ELISA technique.Results MTT OD values of survival cells were lower in MCF-7/ASPP1 and MCF-7/ASPP2 cells than those in MCF-7 cells after the treatment with 25 and 50μmol/L resveratrol,which showed significant differences(P0.05).RT-PCR results showed that after the treatment with 25 and 50μmol/L resveratrol,the levels of Bax and p21mRNA were higher in MCF-7/ASPP1 and MCF-7/ASPP2 cells than those in MCF-7 cells.Apoptosis OD values of death cells were higher in MCF-7/ASPP1 and MCF-7/ASPP2 cells than those in MCF-7 cells after the treatment with 100 and 200μmol/L resveratrol,showing significant differences(P0.05).Conclusion The over-expressions of ASPP1 and ASPP2 improve the sensitivity of MCF-7 cells to resveratrol,and the sensitivity is increased when the concentration is high." @default.
- W2371804889 created "2016-06-24" @default.
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- W2371804889 date "2013-01-01" @default.
- W2371804889 modified "2023-09-24" @default.
- W2371804889 title "Effects of ASPP1 and ASPP2 on apoptosis in resveratrol-induced MCF-7 breast cancer cells" @default.
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