Matches in SemOpenAlex for { <https://semopenalex.org/work/W2371810032> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2371810032 abstract "OBJECTIVE To investigate the curative effect and mechanism of allo-bone marrow mesenchymal stem cell( BM-MSC) infusion in the experimental autoimmune thyroiditis( EAT) mouse model.METHODS An EAT mouse model was established in C57 BL /6 mice using porcine thyroglobulin( PTg)and Freund adjuvant,while BM-MSCs were injected into the EAT mice of BM-MSC treated group,3 ×105per mouse on the 0,7th,14 th and 21 st day. On the 28 th day,all the mice were sacrificed,and thyroid tissue was isolated,embedded in paraffin and stained with HE staining for histological examination.Serum was collected to assess the level of thyroglobulin antibodies( TgAb), thyroid microsomal autoantibodies( TmAb),antithyroid peroxidase antibodies( TPOAb),3,5,3',5'-tetraiodothyronine( TT4),3,5,3'-triiodothyronine( TT3),interleukin-10( IL-10) and interferon-γ( IFN-γ). RESULTS1 Thyroid tissue in model group showed inflammatory response and infiltration. The level of TmAb,TgAb and TPOAb was significantly increased compared with normal control group,but the level of TT4 was decreased while there was no change in the level of TT3,suggesting that an EAT mouse model was established. 2 The thyroid in model group and BM-MSC treated group showed inflammatory response and inflammatory cell infiltration,but the response in BM-MSC treated group was weaker than in model group. 3 Compared with model group,the level of TgAb,TmAb,TPOAb and IFN-γ was decreased obviously( P 0. 05),the level of TT4 and IL-10 was increased significantly( P 0. 05),but the level of TT3 changed little in BM-MSC treated group. CONCLUSION BM-MSCs may partly restore the immunological homeostasis state. The mechanism may be related to its modulation of immune balance of Th1 /Th2." @default.
- W2371810032 created "2016-06-24" @default.
- W2371810032 creator A5061012430 @default.
- W2371810032 date "2014-01-01" @default.
- W2371810032 modified "2023-09-22" @default.
- W2371810032 title "Therapeutical effect and mechanism of allo-bone marrow mesenchymal stem cells in experimental autoimmune thyroiditis" @default.
- W2371810032 hasPublicationYear "2014" @default.
- W2371810032 type Work @default.
- W2371810032 sameAs 2371810032 @default.
- W2371810032 citedByCount "0" @default.
- W2371810032 crossrefType "journal-article" @default.
- W2371810032 hasAuthorship W2371810032A5061012430 @default.
- W2371810032 hasConcept C121332964 @default.
- W2371810032 hasConcept C126322002 @default.
- W2371810032 hasConcept C134018914 @default.
- W2371810032 hasConcept C142724271 @default.
- W2371810032 hasConcept C153400128 @default.
- W2371810032 hasConcept C159654299 @default.
- W2371810032 hasConcept C163764329 @default.
- W2371810032 hasConcept C180650514 @default.
- W2371810032 hasConcept C198826908 @default.
- W2371810032 hasConcept C203014093 @default.
- W2371810032 hasConcept C2776362883 @default.
- W2371810032 hasConcept C2778288131 @default.
- W2371810032 hasConcept C2778696486 @default.
- W2371810032 hasConcept C2778835679 @default.
- W2371810032 hasConcept C2780007613 @default.
- W2371810032 hasConcept C526584372 @default.
- W2371810032 hasConcept C71924100 @default.
- W2371810032 hasConcept C97355855 @default.
- W2371810032 hasConceptScore W2371810032C121332964 @default.
- W2371810032 hasConceptScore W2371810032C126322002 @default.
- W2371810032 hasConceptScore W2371810032C134018914 @default.
- W2371810032 hasConceptScore W2371810032C142724271 @default.
- W2371810032 hasConceptScore W2371810032C153400128 @default.
- W2371810032 hasConceptScore W2371810032C159654299 @default.
- W2371810032 hasConceptScore W2371810032C163764329 @default.
- W2371810032 hasConceptScore W2371810032C180650514 @default.
- W2371810032 hasConceptScore W2371810032C198826908 @default.
- W2371810032 hasConceptScore W2371810032C203014093 @default.
- W2371810032 hasConceptScore W2371810032C2776362883 @default.
- W2371810032 hasConceptScore W2371810032C2778288131 @default.
- W2371810032 hasConceptScore W2371810032C2778696486 @default.
- W2371810032 hasConceptScore W2371810032C2778835679 @default.
- W2371810032 hasConceptScore W2371810032C2780007613 @default.
- W2371810032 hasConceptScore W2371810032C526584372 @default.
- W2371810032 hasConceptScore W2371810032C71924100 @default.
- W2371810032 hasConceptScore W2371810032C97355855 @default.
- W2371810032 hasLocation W23718100321 @default.
- W2371810032 hasOpenAccess W2371810032 @default.
- W2371810032 hasPrimaryLocation W23718100321 @default.
- W2371810032 hasRelatedWork W1986698210 @default.
- W2371810032 hasRelatedWork W2018937811 @default.
- W2371810032 hasRelatedWork W2142507661 @default.
- W2371810032 hasRelatedWork W2298668783 @default.
- W2371810032 hasRelatedWork W2352618537 @default.
- W2371810032 hasRelatedWork W2368129309 @default.
- W2371810032 hasRelatedWork W2371224241 @default.
- W2371810032 hasRelatedWork W2376440078 @default.
- W2371810032 hasRelatedWork W2382254104 @default.
- W2371810032 hasRelatedWork W2385444019 @default.
- W2371810032 hasRelatedWork W2389046898 @default.
- W2371810032 hasRelatedWork W2393833005 @default.
- W2371810032 hasRelatedWork W2756103197 @default.
- W2371810032 hasRelatedWork W2808168677 @default.
- W2371810032 hasRelatedWork W2885750061 @default.
- W2371810032 hasRelatedWork W2981120723 @default.
- W2371810032 hasRelatedWork W2997172899 @default.
- W2371810032 hasRelatedWork W3025645899 @default.
- W2371810032 hasRelatedWork W3203712690 @default.
- W2371810032 hasRelatedWork W45096280 @default.
- W2371810032 isParatext "false" @default.
- W2371810032 isRetracted "false" @default.
- W2371810032 magId "2371810032" @default.
- W2371810032 workType "article" @default.