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- W2371815902 abstract "Objective To investigate the effect Peptide YY on L-Arginine induced acute pancreatitis(AP) in rats and explore its possible mechanism.Methods 40 Sprague-Dawley rats were divided into AP group and Peptide YY therapy group.AP model was induced by injecting 6% L-Arginine(1.2 mg/g×3) into belly cavity,levels of TNF-α and MDA(malondialdehyde) were measured in serum and pancreas homogenate.Pathologic alteration of pancreatic tissues was also observed.Results Levels of TNF-α and MDA in serum and pancreatic homogenate Peptide YY therapy group were significantly lower than those in AP group(P 0.05).Conclusion The results suggest that Peptide YY possesses a therapeutic effect on the AP,in which the mechanism might be due to prevent from the production of reactive oxygen metabolites,attenuate the injury of per oxidation,and reduce the levels of inflammatory mediators." @default.
- W2371815902 created "2016-06-24" @default.
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- W2371815902 date "2012-01-01" @default.
- W2371815902 modified "2023-09-26" @default.
- W2371815902 title "Therapeutic effect of Peptide YY on experimental acute pancreatitis" @default.
- W2371815902 hasPublicationYear "2012" @default.
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