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- W2371821355 abstract "Objective To observe the effects of RNAi-mediated focal adhesion kinase (FAK) gene silencing on laryngeal carcinoma Hep-2 cells. Methods Recombinant plasmids generating short hairpin RNA were constructed, including two interferential sequences FAK-pGenesil-CH1, FAK-pGenesil-CH2 and one negative control sequence FAK-pGenesil-HK. Hep-2 cells were transfected with recombinant plasmids. FAK mRNA and protein were analyzed respectively by RT-PCR and Western blotting. Cell proliferation, cell cycle and invasion of Hep-2 cells were observed by MTT assay, flow cytometry and transwell invasion assay, respectively. Results Recombinant plasmids of FAK-pGenesil-CH1 and FAK-pGenesil-CH2 downregulated the expressions of FAK mRNA and protein (P0.05). The proliferation inhibition ratio in Hep-2 cells reached 58.34% and 52.78% 48 h after transfection of recombinant plasmids of FAK-pGenesil-CH1 and FAK-pGenesil-CH2, while that was 8.34% in the control (P0.05). More cells arrested in G0/G1 phase in the transfected groups than controls. The number of FAK-pGenesil-CH1 transfected Hep-2 cells, and FAK-pGenesil-CH2 transfected Hep-2 cells through Matrigel membrane was (56.0±6.7) and (51.0±5.1), respectively, significantly less than that in control groups (P0.05). Conclusion The constructed recombinant plasmids of FAK-pGenesil-CH1 and FAK-pGenesil-CH2 can suppress the expression of FAK mRNA and protein in Hep-2 cells, and inhibit the cloning and invasion of Hep-2 cells." @default.
- W2371821355 created "2016-06-24" @default.
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- W2371821355 date "2009-01-01" @default.
- W2371821355 modified "2023-09-26" @default.
- W2371821355 title "Effect of focal adhesion kinase gene silencing on proliferation and invasion of Hep-2 cells" @default.
- W2371821355 hasPublicationYear "2009" @default.
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