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- W2371830961 abstract "Objective To investigate the effect of transcatheter arterial chemoembolization(TACE) with As_2O_3 and lipiodol on growth and angiogenesis of hepatic tumor.Methods Thirty-two New Zealand white rabbits were randomly divided into four groups and VX2 carcinoma was implanted in the left lobes of the liver.Two weeks later,a catheter was inserted into the hepatic artery of the rabbit with VX2 hepatic tumor and infusion was performed via the hepatic artery with physiological saline,As_2O_3,lipiodol,emulsion of As_2O_3 and lipiodol.The size of the tumor was observed by sonography,its volume and growth rate were calculated,its blood flow was studied by power Doppler sonography before and after intravenous administration of a microbubble contrast agent one week after treatment.Mean color vessel density(MCVD) was calculated,necrotic rate of the tumor was assessed by routine histology,microvessel density(MVD) of the tumor was examined by immunohistochemistry.Results Growth of the tumor was suppressed in embolization groups.Necrotic rate of the tumor was higher in As_2O_3 and lipiodol embolization group than in single lipiodol embolization group.Blood flow of the tumor revealed by unenhanced or contrast-enhanced power Doppler sonography was significantly decreased after embolization treatment,the difference was not statistically significant before using microbubble contrast agent,but statistically significant after using microbubble contrast agent.MVD was slightly higher in single lipiodol embolization group((23.4)±(4.7)) vs physiological saline group((21.8)±(6.3))(P(0.05)),MVD was significantly lower in As_2O_3 and lipiodol embolization group((15.1)±(3.2))(P(0.05)).Conclusions TACE with As_2O_3 and lipiodol suppresses the growth of tumor,increase the tumor necrotic rates,inhibits the development of neovascularization of residual tumors.Contrast-enhanced power Doppler sonography is a useful technique for assessing the blood flow of residual tumors after TACE treatment." @default.
- W2371830961 created "2016-06-24" @default.
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- W2371830961 date "2005-01-01" @default.
- W2371830961 modified "2023-09-25" @default.
- W2371830961 title "Assessing therapeutic effects of transcatheter arterial embolization for rabbits with VX2 hepatic implanted tumor using ultrasonography" @default.
- W2371830961 hasPublicationYear "2005" @default.
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