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- W2371869976 abstract "Objective To investigate the effcets of somatostatin analogue octreotide on the growth of gastric cancer SGC-7910 in vivo. Methods The forty-eight nude mice of xenotransplanted human gastric cancer cell line SGC-7901 in gymnomouse body were set up. On the eighth day, all nude mice were randomly divided into four groups and each group had twelve mice. Octreotide at a dose of 100ug/kg was subcutaneously administered once a day in Octreotide group. 5-FU was intraperitoneally administered twice a week in 5-FU group. Combined group receivel all the reagents as Octreotide group and 5-FU group.Control group received injection of NS.Six weeks later,all mice were executed.The tumor mass volume,weight,necrosis volume were observed and the inhibition rate of tumor growth were also caculated.Results The average tumor volumes(cm3) in Octreotide group, 5-FU group, combined group and control group was 2.17±0.78,2.19±0.79,1.36±0.75 and 3.23±0.74 respectively (F=9.317,P=0.0001).The average tumor weight (g) was 6.88±2.06, 7.22±2.47, 4.47±2.28 and 10.30±2.80(F=5.452, P=0.0001). The average tumor necrosis volume(cm3) was 0.55±0.38, 0.52±0.53, 1.14±0.83 and 0.32±0.27(F=13.987, P=0.0001), and the average tumor inhibition rate in Octreotide, 5-FU and Combined group was 33.20%、29.92%、56.60% respectively(χ2=6.461,P=0.04).Conclusion Octreotide could inhibit the SGC-7901 growth in vivo." @default.
- W2371869976 created "2016-06-24" @default.
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- W2371869976 date "2006-01-01" @default.
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- W2371869976 title "Inhibitory effects of octreotide on the growth of gastric cancer line SGC-7901 in vivo" @default.
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