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- W2371882972 abstract "AIM:To study the role of heme oxygenase (HO)-1 in the mechanism of cholecystokinin-octapeptide (CCK-8) for attenuation of acute lung injury (ALI) induced by lipopolysaccharide (LPS). METHODS: Adult male rats were randomly divided into five groups: control group, LPS group, CCK-8+LPS group, LPS+ Hm (hemin, HO-1 donor) group and LPS+ZnPP (zinc protoporphyrin, specific inhibitor of HO-1) group. PMN number in bronchoalveolar lavage fluid (BALF), the structure of the lung, MDA content, HO-1 activity, the expressions of HO-1 mRNA and protein in the lung were detected respectively. RESULTS: The lung injury in LPS group was observed, at the same time the numbers of PMN, the content of MDA, the activity and the expression of HO-1 were all higher than those in control group (all P0.05). The degree of lung injury, PMN numbers and MDA content were lower, while the activity and the expression of HO-1 in CCK-8+LPS and LPS+Hm group were higher than those in LPS group (all P0.05). However, the degree of lung injury, PMN numbers and MDA content were higher, the activity and the expression of HO-1 were lower in LPS+ZnPP than those in LPS group respectively (all P0.05). CONCLUSION: CCK-8 attenuates the LPS-induced ALI by means of anti-oxidation and inhibits PMN aggregation, which are both mediated by HO-1 partly." @default.
- W2371882972 created "2016-06-24" @default.
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- W2371882972 date "2007-01-01" @default.
- W2371882972 modified "2023-09-26" @default.
- W2371882972 title "Role of heme oxygenase in cholecystokinin octopeptide ameliorating acute lung injury induced by lipopolysaccharide" @default.
- W2371882972 hasPublicationYear "2007" @default.
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