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- W2371885873 abstract "Objective To explore the relationship between the markers of prethrombotic state(PTS) and left ventri- cular function in ischemic heart failure. Methods The levels of fibrinogen(Fg),P-selectin,tissue plasminogen activator(t-PA),plasminogen activator inhibitor-1 (PAI-1),D-dimer were observed in 118 patients(New York Heart Association class Ⅱ-Ⅳ) with ischemic heart failure. Echocardiography was applied to measure left ventricular ejection fraction(LVEF). 45 patients of NYHA class Ⅱ were randomly divided into three groups: fosinopril group, valsartan group and bisoprolol group. 3 months after drugs administration, the markers of PTS were examined again. Results There were significant difference in the levels of the markers of PTS with more severe sympotoms(NYHA class Ⅱ-Ⅳ),and the significant changes has close relationship with LVEF. After fosinopril or valsartan was introduced, the levels of Fg,vwF, P-selectin(P0.05,respectively), D-dimer,PAI-1(P0.01,respectively) were significantly decreased and the level of t-PA significantly increased(P0.01),but there was no significant difference between the two groups. There were no significant changes in the markers after the introduction of bisoprolol(P0.05). Conclusion PTS is present in ischemic heart failure, especially in those with more severe NYHA class. Treatment with ACEI or ARB can improve PTS with CHF, whereas the addition of β-blockers is not effective." @default.
- W2371885873 created "2016-06-24" @default.
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- W2371885873 date "2004-01-01" @default.
- W2371885873 modified "2023-09-25" @default.
- W2371885873 title "The relationship between the markers of prethrombotic state and the left ventricular function in ischemic heart failure" @default.
- W2371885873 hasPublicationYear "2004" @default.
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