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- W2371888167 abstract "Fifty strains of poliovirus, predo-minantly Type Ⅰ, and 19 strains of non-polioviruses, including Types A9, B3, B4and B5 of Coxsackie virus, Types 6 and16 of ECHO virus, and Type 3 ofadenovirus, were isolated from 100children with flaccid paralysis vaccinatedwith Chinese made orally administeredSabin's live attenuated poliovirus vaccinein 1963--1964. 149 and 89 strains ofpoliovirus, also predominantly Type Ⅰ,and 25 and 23 strains of nonpoliovi-ruses, including Types A9 and B4 ofCoxsackie virus, Types 6, 8 and 16 ofECHO virus, and Type 3 of adenovirus,were recovered from 368 and 188 unvac-cinated children with flaccid paralysis in1963--1964 and 1959--1962 respectively.Based on the increase in titer of neutra-lizing antibodies in paired sera, the ma-jority of the virus strains isolated wereconsidered to be the etiologic agents inthese cases. Of the 50 vaccinated children withflaccid paralysis from whom polioviruswas isolated, 21 developed paralyticillness 4--30 days (corresponding to theincubation period of poliovirus infection)following vaccination. In 17 of these 21cases the virus isolated was of the sametype as the vaccine virus. In the remaining 29 of the 50vaccinated children with paralysis, theillness occurred in less than 4 days in 7cases and over 30 days in 22 cases aftervaccination. All the 50 strains of poliovirusrecovered from the vaccinated childrenwith flaccid paralysis were subjected tothe T marker test. The results showedthat the T coefficient of all the strainswas less than 0.29, indicating that theywere virulent but not attenuated strains.These cases were thus considered to becoincidental cases, possibly due to infec-tion with wild strains of poliovirusexisting in nature." @default.
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- W2371888167 date "1973-01-01" @default.
- W2371888167 modified "2023-09-25" @default.
- W2371888167 title "ETIOLOGY OF FLACCID PARALYSIS IN CHILDREN VACCINATED AND UNVACCINATED AGAINST POLIOMYELITIS" @default.
- W2371888167 hasPublicationYear "1973" @default.
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