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- W2371889124 abstract "A simple,sensitive and rapid liquid chromatographic-electro-spray ionization tandem mass spectrometric method was developed for the quantification of nebivolol in human plasma.Amlodipine was used as the internal standard(IS).Separation was performed using a Shimadzu C18 column(150 mm×2.0 mm,4.6 μm) maintained at 35 ℃ and the mobile phase consisting of a mixture of acetonitrile and water(containing 0.05% formic acid)(45∶ 55) was delivered at a flow rate of 0.2 mL/min;The analytes were analyzed by electro-spray ionization(ESI) in the selected reaction monitoring mode.The precursor to product ion transitions of m/z 406.2-151.0 and m/z 409.0-238.2 were used to measure nebivolol and the IS,respectively.The linearity ranged from 0.025 to 25 ng/mL(r = 0.998 6);and the limit of detection of nebivolol in human plasma was 0.008 ng/mL.The recovery,intra-and inter-assay precisions met the requirements of bioanalytical method.The t1/2,AUC0-t,cmax,MRT of nebivolol in healthy volunteers were(14.4±5.5) h,(7.35±2.48) ng ·h/mL,(1.05±0.35) ng/mL,and(16.5±5.3) h for a single oral dose of 5 mg nebivolol,respectively.The method is selective and suitable for the quantification of nebivolol in human plasma." @default.
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- W2371889124 date "2011-01-01" @default.
- W2371889124 modified "2023-09-26" @default.
- W2371889124 title "Determination of nebivolol in human plasma by LC-MS/MS and study of its pharmacokinetics on the Chinese" @default.
- W2371889124 hasPublicationYear "2011" @default.
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