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- W2371912963 abstract "By means of trans-dermal permeation on rat skin in vitro,the effect of low-frequency ultrasound(40 kHz) on trans-dermal permeation of(Protein transduction domain-superoxide dismutase,PTD-SOD) has been inves-tigated.The results show that the enhancement ratios of ultrasound and Azone are 3.40 and 2.52,respectively,when the trans-dermal permeation time is 8 h.In the presence of low-frequency ultrasound,when the initial pH value of drug solution is 6.0,the activity of PTD-SOD in receiver cell reaches 1598.00 U,the maximum value.Under the ac-tion of low-frequency ultrasound,the trans-dermal permeation of drug varies as a function of the initial PTD-SOD concentration according with a Fick-type scattering law,and the coefficient of permeation is 0.011.These results demonstrate that Low-frequency ultrasound can significantly improve trans-dermal transport of PTD-SOD,and the effect is superior to Azone.Both of the initial pH value of drug solution and the initial PTD-SOD concentration can affect the permeation rate of the PTD-SOD.And the best initial pH value and drug concentration is 6.0 and 15.00kU·mL-1,respectively." @default.
- W2371912963 created "2016-06-24" @default.
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- W2371912963 date "2011-01-01" @default.
- W2371912963 modified "2023-09-23" @default.
- W2371912963 title "Effect of low-frequency ultrasound on trans-dermal permeation of fusion protein PTD-SOD in vitro" @default.
- W2371912963 hasPublicationYear "2011" @default.
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