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- W2371921658 abstract "In guinca pigs with the experimental heart failure induced by pentobarbital sodium,intravenous infusion of different doses of sophoridine (5,10,or 20 mg/kg) increased LV±dp/dt max,LVSP,MAP,HR,LVEDP,and decreased LVEDP.Maximal effect occured 1 min after administration. Such effects were statistically significant in comparision with the control.After intravenous infusion of strophanthin K (90 μg/kg),in parallel experiment,LV±dp/dt max,LVSP,MAP,and HR were increased more than sophoridine. The content of myocardium Ca2+was increased by sophoridine,but less than strophanthin K.The results showed that sophoridine improved cardiac performance in guinea pigs with experimental heart failure.Its machanism possibly related to that sophoridine increased content of myocardium Ca2+." @default.
- W2371921658 created "2016-06-24" @default.
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- W2371921658 date "1998-01-01" @default.
- W2371921658 modified "2023-09-28" @default.
- W2371921658 title "EFFECT OF SOPHORIDINE ON EXPERIMENTAL HEART FAILURE IN GUINEA PIG" @default.
- W2371921658 hasPublicationYear "1998" @default.
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