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- W2371921837 abstract "Aim To investigate whether the changing of the side chain of polarity may alter the antitumor effect of the oxysterols.Method Starting from hyodesoxycholic acid,22 compounds were synthesized(among them,14 were new ones).Ring A and B of these compounds bear the structural features of 3 β ,5 α ,6 β trihydroxy or 3 β ,6 β dihydroxy Δ 4 ene and their side chains all possess a varied degree of polarity.Compared with 3 β ,5 α ,6 β thihydroxycholestane(10)and 3 β ,6 β dihydroxycholest 4 ene(11)respectively, in vitro antitumor activities of these 22 compounds were tested with murine L 1210 leukemia cell line.Result and conclusion For most of the compounds tested,no evident change on antitumor effect had been observed,although a few had slightly stronger effect and some of them lost their activity.Therefore,the goal to obtain antitumor oxysterols with stronger activity has not yet been achieved through synthesizing cholanic acid derivatives with sturctural features of 3 β ,5 α ,6 β triol and/or 4 ene 3 β ,6 β diol." @default.
- W2371921837 created "2016-06-24" @default.
- W2371921837 creator A5008320764 @default.
- W2371921837 date "2004-01-01" @default.
- W2371921837 modified "2023-10-05" @default.
- W2371921837 title "Study on the antitumor activity of hydroxycholanic acid derivatives Synthesis and in vitro antitumor activity of 3β ,5α ,6-trihydroxycholanic acid derivatives and 3β ,6β-dihydroxychol-4-enic acid derivatives" @default.
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