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- W2371927909 abstract "Objective:To examine the regulatory effect of corticotrophin-releasing hormone(CRH) on glutamate-mediated current(IGLU) in cultured hippocampal neurons and to study the related mechanism.Methods: Immunofluorescence analysis was used to investigate whether the cultured hippocampal neurons express CRH receptors,and the whole-cell patch-clamp technique was used to examine the direct modulation of CRH on IGLU and the possible intracellular signal pathway.Results: Two minutes' exposure to CRH obviously depressed IGLU in the neurons in a dose-dependent manner.CRH receptor antagonist α-helical CRH or CRH receptor type 1(CRHR1) antagonist antalarmin completely blocked CRH-induced depression of IGLU;whereas,CRH receptor type 2(CRHR2) antagonist astressin-2B failed to block the effects of CRH.Application of the PKC inhibitor G6976 totally blocked the CRH-induced decrease of IGLU.Conclusion: CRH can inhibit IGLU in primary cultured hippocampal neurons,which is mediated by CRHR1 and may involve the PKC signal pathway." @default.
- W2371927909 created "2016-06-24" @default.
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- W2371927909 date "2009-01-01" @default.
- W2371927909 modified "2023-09-25" @default.
- W2371927909 title "Regulatory effect of corticotrophin-releasing hormone on glutamate-mediated current in cultured hippocampal neurons" @default.
- W2371927909 hasPublicationYear "2009" @default.
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