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- W2371936166 abstract "Objective: To investigate the effect of julibroside J12 on apoptosis of human microvascular endothelial cells(HMEC-1).Methods: After HMEC-1 cells were treated with different concentrations of julibroside J12 for various durations,the inhibition of cell growth was detected by SRB assay,typical apoptotic morphological features were observed by the TUNEL and DAPI fluorescent staining.The apoptotic rate and the voltage(ΔΨm) of mitochondria were measured by flow cytometry.The activity of caspase-3 and-9 was detected by spectrophotometry.Results: Julibroside J12 inhibited the growth of HMEC-1 cells and induced apoptosis(up to 75.6%).Flow cytometric analysis showed that HMEC-1 cell cycle was arrested at the G2/M phase,and the subdiploid peak with apoptotic DNA characteristics was observed,and the apoptosis rate was about 19.49%.However,the voltage(ΔΨm) of mitochondria did not drop,and the activity of caspase-3 and-9 also did not increase significantly in HMEC-1 cells treated by julibroside J12.Conclusion: Julibroside J12 can inhibit the proliferation of HMEC-1 cells by inducing apoptosis,and julibroside J12-induced apoptosis of HMEC-1 cells might not relate to mitochondria." @default.
- W2371936166 created "2016-06-24" @default.
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- W2371936166 date "2011-01-01" @default.
- W2371936166 modified "2023-09-22" @default.
- W2371936166 title "Effect of julibroside J_(12) on apoptosis of human microvascular endothelial cells" @default.
- W2371936166 hasPublicationYear "2011" @default.
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