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- W2371936563 abstract "Objective To investigate the clinical effects of olanzapine combined with escitalopram in treatment of older women with refractory depression. Methods The patients(83 cases) with refractory depression in Beijing Shunyi District Mental Hospital from June 2012 to December 2014 were randomly divided into control(41 cases) and treatment(42 cases) groups. The patients in the control group were po administered with Escitalopram Oxalate Tablets 5 mg/d. After 2 — 4 weeks, the dosage was gradually increased to 10 — 20 mg/d. On the basis of control group, the patients in the treatment group were po administered with Olanzapine Tablets 2.5 mg/d in the evening. After 2 — 4 weeks, the dosage was gradually increased to 3.75 — 5 mg/d in the evening. Two groups were treated for 12 weeks. Hamihon depression scale(HAMD) and Hamiton anxiety scale(HAMA) were assessed, and glucose(GLU), lipid indexes total cholesterol chol(CHOL), triacylglycerol(TG), low density lipoprotein(LDL), high density lipoprotein(HDL), and body mass index(BMI) were compared, and treatment-emergent signs and symptoms(TESS) were used to assess adverse reactions. Results The clinical efficacy in treatment group(65.9%) was higher than that in control group(42.5%) with significant difference(P 0.05). After treatment for 4, 6, 8, and 12 weeks, HAMD scores of two groups were improved more than those before treatment, and the difference was significant(P 0.05, 0.01); After treatment for 6, 8, and 12 weeks, HAMD scores of treatment group were improved more than those of control group with significant difference(P 0.05). After treatment for 4, 6, 8, and 12 weeks, HAMA scores of control group were improved more than those before treatment, and the difference was significant(P 0.05, 0.01); After treatment for 2, 4, 6, 8, and 12 weeks, HAMA scores of treatment group were improved more than those before treatment with significant difference(P 0.05, 0.01). After treatment for 2, 6, and 12 weeks, there was no significant difference in GLU, CHOL, TG, HDL, LDL, and BMI of two groups, compared with those before treatment. And there was no significant difference in these obvervational indexes of treatment group, compared with those in control group at the same period. The incidence of adverse events of two groups was not statistically significant. Conclusion Olanzapine combined with escitalopram has good effect in treatment of older women with refractory depression, and is safer, which has a certain clinical application value." @default.
- W2371936563 created "2016-06-24" @default.
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- W2371936563 date "2015-01-01" @default.
- W2371936563 modified "2023-09-24" @default.
- W2371936563 title "Clinical observation of olanzapine combined with escitalopram in treatment of older women with refractory depression" @default.
- W2371936563 hasPublicationYear "2015" @default.
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