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- W2371947355 abstract "Objective: To explore low birth weight(LBW) in offspring in association with mother′s Methylenetetrahydrofolate reductase(MTHFR) gene C677T and Cystathionine β-synthase(CBS) gene T833C.Methods: we identified mothers′ genetic polymorphisms of MTHFR and CBS by PCR-RFLP and PCR-ARMS respectively.The relationship between LBW and MTHFR gene C677T,CBS gene T833C,synergism of genotypes were analysed.Results: Both genetic polymorphisms of MTHFR and CBS were not significantly associated with LBW(P0.05),respectively,but there was the interaction in relation to LBW among MTHFR mutational genotype and CBS mutational genotype(OR=3.155,95%CI:1.229~8.528).Conclusion: Both of MTHFR gene C677T and CBS gene T833C are not associated with LBW.It is suggested that there is synergism of MTHFR mutational genotype and CBS mutational genotype,which may cause LBW in offspring." @default.
- W2371947355 created "2016-06-24" @default.
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- W2371947355 date "2009-01-01" @default.
- W2371947355 modified "2023-09-23" @default.
- W2371947355 title "Association of low birth weight with genetic polymorphisms of MTHFR and CBS in mother." @default.
- W2371947355 hasPublicationYear "2009" @default.
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