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- W2371965564 abstract "Objective:To observe the expression of c-fos and caspase-3 protein in geriatric rats hippocampus CA3 area induced by chronic unpredictable mild stress in order to understand the nosogenesis of depression.Methods:Twenty geriatric Wistar rats were randomizedly and equally divided into experimental group and control group.In experimental group,rats were forced to swim 20 minutes each day plus electricity stimulation and tail sting once a week,in control group,no special intervention were added.After 21 days,the expression of c-fos and caspase-3 protein were detected by immunohistochemistry marked by special antibodies,meanwhile,the open-field behavior and defecation condition before and after experiment were observed.Results:In experimental group,geriatric rats showed prolonged immobility time,ambulation and modification time decreased,feces increased;c-fos mean gray scale(202.59±2.64 vs 179.74±8.24,P=0.000),positive cell numbers(41.12±4.72 vs 31.12±3.25,P=0.000),caspase-3 mean gray scale(202.59±2.64 vs 179.74±8.24,P=0.000)and positive cell numbers(24.73±2.57 vs 18.86±1.13,P=0.000) were higher than in control group.Conclusion:The expression of c-fos and caspase-3 protein increased in hippocampus CA3 area of geriatric rats induced by chronic unpredictable mild stress,and behaviors showed abnormal,which might be related to the up-regulation of cell apoptosis and the brain damage in hippocampus induced by chronic stress." @default.
- W2371965564 created "2016-06-24" @default.
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- W2371965564 date "2008-01-01" @default.
- W2371965564 modified "2023-09-25" @default.
- W2371965564 title "Expression of c-fos and Caspase-3 Protein in Geriatric Rats Hippocampus CA3 Area Induced by Chronic Unpredictable Mild Stress" @default.
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