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- W2371969770 abstract "Objective To investigate the expression of CXCR4 in human ovarian cancer cells and the relationship between SDF- 1/CXCR4 system and the malignity of ovarian cancer cells. Methods Expression of CXCR4 mRNA in ovarian cancer cell line SW626 was detected by reverse transcriptase- polymerase chain reaction (RT- PCR); the proliferation of SW626 cells was identified by MTT method; Transwell was used to analyze the migration of SW626 cells in presence of SDF- 1 or when CXCR4 was blocked by anti- CXCR4 McAb. Results CXCR4 mRNA was expressed in SW626 cells; anti- CXCR4 McAb (20 μ g/mL) inhibited the proliferation of SW626 cells(P 0.05); SDF- 1 induced the migration of SW626 cells, which could be effectively blocked by anti- CXCR4 McAb(P 0.05). Conclusion SDF- 1 and CXCR4 may play an important role in the proliferation and migration of ovarian cancer cells, and interfering the interaction of SDF- 1 and CXCR4 can be a meaningful therapeutic target and strategy." @default.
- W2371969770 created "2016-06-24" @default.
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- W2371969770 date "2006-01-01" @default.
- W2371969770 modified "2023-09-25" @default.
- W2371969770 title "Effects of chemokine stromal cell- derived factor-1 and its receptor CXCR4 on the proliferation and migration of ovarian cancer cells" @default.
- W2371969770 hasPublicationYear "2006" @default.
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