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- W2371974744 abstract "Ryanodine receptor is the main intracellular Ca channel residing in the sarcoplasmic reticulum (SR) and is responsible for the release of Ca 2+ from the SR. The impaired ability to handle intracellular calcium due to changes in ryanodine receptor may be an important proarrhythmia mechanism in hypertrophied ventricle. Over-activity of sympathetic nervous system or overload of [Ca 2+] SR will increase the sensitivity of RyR to [Ca 2+] i causing spontaneous Ca 2+ release, which is related to the occurrence of delayed or early afterdepolarizations and dispersion of repolarization in ventricular myocardium, and thus, may contribute to triggered activity and other ventricular arrhythmias." @default.
- W2371974744 created "2016-06-24" @default.
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- W2371974744 date "2005-01-01" @default.
- W2371974744 modified "2023-09-23" @default.
- W2371974744 title "Ryanodine receptor and arrhythmia" @default.
- W2371974744 hasPublicationYear "2005" @default.
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