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- W2371998914 abstract "15-Methyl prostaglandin F_(2α)(15-MPGF_(2α))and all its congeners tested inthis study could induce diarrhea after giving orally to mice.The purgative ef-fect induced by 15-MPGF_(2α)was the most marked,and was more than three timesthat by prostaglandin F_(2α)and ten times that by 13 dehydro-ω-ethyl prostaglan-din F_(2α)The relative potencies of the purgative effects of 15(S)-15-methyl pro-staglandin F_(2α)(S),racemic 15-methyl prostaglandin F_(2α)(15-MPGF_(2α)) and15-(R)-15-methyl prostaglandin F_(2α)(R) were 7:2.5:1.The 15-MPGF_(2α)induced diarrhea in mice could be antagonized by subcu-taneously administered morphine,atropine and diphenoxylate.These protectiveeffects correlated well with the doses used.In mice,subcutaneous injection of 15-MPGF_(2α))could significantly hasten thepassage of charcoal from stomach to the appendix,and this effect could be partiallyabolished by orally administered diphenoxylate.When 15-MPGF_(2α)(1 mg/kg)was injected subcutaneously to rats,it incre-ased the amount of intestinal fluid from the control value of 0.7±0.11 ml to 2.8±0.24 ml,the sodium content from 0.068±0.01 mEq to 0.31±0.03 mEq andpotassium content from 0.016±0.003 mEq to 0.046±0.030 mEq.This doseof 15-MPGF_(2α)could not alter significantly the content of cAMP in the mucosa ofthe ileum,and aminophylline did not exert any significant influence on the effectof 15-MPGF_(2α).Injection of 15-MPGF_(2α)directly into the rat intestinal lumenalso resulted in the increase in the amount of intestinal fluid,sodium and potas-sium content.The results of the present study reveal that the purgative effect induced by15-MPGF_2 might mainly be due to its direct stimulatory action on the intestinalsmooth muscle,and the accumulation of a large amount of water and sodiumwithin the intestinal lumen.However,the role of its stimulation on the choli-nergic system should not be neglected.Water and sodium accumulation in theintestine induced by 15-MPGF_(2α)seems to be unrelated to the adrenocorticoste-roides and local cAMP content." @default.
- W2371998914 created "2016-06-24" @default.
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- W2371998914 date "1980-01-01" @default.
- W2371998914 modified "2023-09-23" @default.
- W2371998914 title "ON THE MECHANISM OF DIARRHEA INDUCED BY 15-METHYL PROSTAGLANDIN F_(2α)AND ITS ANALOGUES" @default.
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