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- W2372002699 abstract "Aim:To study the effects of compound Ⅰb as a new angiotensin type 1 receptor antagonist on isoproterenol-induced cardiac hypertrophy in rats.Methods:Cardiac hypertrophy in rats was induced by subcutaneous administration of isoproterenol in which the dosage schedule was set to 20 mg/kg in the 1st day,10 mg/kg in the 2nd day,5 mg/kg in the 3rd day,and 3mg/kg in the following consecutive seven days.Compound Ⅰb was given to rats via tail vein in the 7th day.Cardiac mass index,malondialdehyde(MDA) content of cardiac muscle,the activity of cardiac muscle superoxide dismutase(SOD)and the lactate dehydrogenase(LDH) released to the serum were observed.Results:It was shown that at a dose of 3mg/kg Ⅰb improved the cardiac mass index,significantly decrease MDA content of the cardiac muscle,increased the activity of cardiac muscle SOD,and significantly decreased the LDH released to the serum.Electron microscope showed that Ib improved the structure of cardiac muscle fiber and mitochondria.Cardiac muscle fiber lined up in order,and Z line was clear.Conclusion:Compound Ⅰb was shown to be effective against isoproterenol-induced cardiac hypertrophy in rats." @default.
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- W2372002699 date "2007-01-01" @default.
- W2372002699 modified "2023-09-26" @default.
- W2372002699 title "Effects of a new angiotensin type 1 receptor antagonist Ib on isoproterenol-induced cardiac hypertrophy in rats" @default.
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