Matches in SemOpenAlex for { <https://semopenalex.org/work/W2372009957> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2372009957 abstract "To evaluate the safety of the therapeutic DNA vaccine against the hepatitis B virus. Plasmid DNA was detected by PCR in tissues of BALB/c mice immunized with the plasmids combined with electrotransfer in doses of 10 and 50μg. In long term toxicity study, HBV DNA vaccine was administered by repeated intramuscular injections combined with electrotransfer of pDNA to NIH mice in doses of 30, 60 and 120μg, twice a week for four consecutive weeks. Morbid manifestations, behaviors, hematology, blood chemistry, anti nuclear antibodies, and histopathology were analyzed. Results showed that plasmid DNA was detected primarily in the muscle at the site of injection, where it remained for up to 8 weeks. Eight repeated intramuscular injections of HBV DNA vaccine showed no adverse effects on behaviors, hematology, blood chemistry, and histopathology. No evidences of autoimmune mediated pathology and anti nuclear antibodies were observed in the mice. These results suggested that the therapeutic HBV DNA vaccine was safe and well tolerated." @default.
- W2372009957 created "2016-06-24" @default.
- W2372009957 creator A5002228545 @default.
- W2372009957 date "2003-01-01" @default.
- W2372009957 modified "2023-09-23" @default.
- W2372009957 title "A STUDY OF DISTRIBUTION IN THE TISSUES AND LONG-TERM TOXICITY OF THERAPEUTIC DNA VACCINE IN MICE" @default.
- W2372009957 hasPublicationYear "2003" @default.
- W2372009957 type Work @default.
- W2372009957 sameAs 2372009957 @default.
- W2372009957 citedByCount "0" @default.
- W2372009957 crossrefType "journal-article" @default.
- W2372009957 hasAuthorship W2372009957A5002228545 @default.
- W2372009957 hasConcept C126322002 @default.
- W2372009957 hasConcept C142724271 @default.
- W2372009957 hasConcept C159047783 @default.
- W2372009957 hasConcept C159654299 @default.
- W2372009957 hasConcept C167508917 @default.
- W2372009957 hasConcept C194409129 @default.
- W2372009957 hasConcept C197934379 @default.
- W2372009957 hasConcept C203014093 @default.
- W2372009957 hasConcept C22744801 @default.
- W2372009957 hasConcept C2776291583 @default.
- W2372009957 hasConcept C2780801004 @default.
- W2372009957 hasConcept C29730261 @default.
- W2372009957 hasConcept C544855455 @default.
- W2372009957 hasConcept C552990157 @default.
- W2372009957 hasConcept C55493867 @default.
- W2372009957 hasConcept C71924100 @default.
- W2372009957 hasConcept C86803240 @default.
- W2372009957 hasConcept C98274493 @default.
- W2372009957 hasConceptScore W2372009957C126322002 @default.
- W2372009957 hasConceptScore W2372009957C142724271 @default.
- W2372009957 hasConceptScore W2372009957C159047783 @default.
- W2372009957 hasConceptScore W2372009957C159654299 @default.
- W2372009957 hasConceptScore W2372009957C167508917 @default.
- W2372009957 hasConceptScore W2372009957C194409129 @default.
- W2372009957 hasConceptScore W2372009957C197934379 @default.
- W2372009957 hasConceptScore W2372009957C203014093 @default.
- W2372009957 hasConceptScore W2372009957C22744801 @default.
- W2372009957 hasConceptScore W2372009957C2776291583 @default.
- W2372009957 hasConceptScore W2372009957C2780801004 @default.
- W2372009957 hasConceptScore W2372009957C29730261 @default.
- W2372009957 hasConceptScore W2372009957C544855455 @default.
- W2372009957 hasConceptScore W2372009957C552990157 @default.
- W2372009957 hasConceptScore W2372009957C55493867 @default.
- W2372009957 hasConceptScore W2372009957C71924100 @default.
- W2372009957 hasConceptScore W2372009957C86803240 @default.
- W2372009957 hasConceptScore W2372009957C98274493 @default.
- W2372009957 hasLocation W23720099571 @default.
- W2372009957 hasOpenAccess W2372009957 @default.
- W2372009957 hasPrimaryLocation W23720099571 @default.
- W2372009957 hasRelatedWork W2031696481 @default.
- W2372009957 hasRelatedWork W2037415680 @default.
- W2372009957 hasRelatedWork W2046019984 @default.
- W2372009957 hasRelatedWork W2088978732 @default.
- W2372009957 hasRelatedWork W2121670358 @default.
- W2372009957 hasRelatedWork W2200403145 @default.
- W2372009957 hasRelatedWork W2263857803 @default.
- W2372009957 hasRelatedWork W2333383965 @default.
- W2372009957 hasRelatedWork W2347790016 @default.
- W2372009957 hasRelatedWork W2350762479 @default.
- W2372009957 hasRelatedWork W2351677845 @default.
- W2372009957 hasRelatedWork W2367244505 @default.
- W2372009957 hasRelatedWork W2370988788 @default.
- W2372009957 hasRelatedWork W2374817682 @default.
- W2372009957 hasRelatedWork W2375842025 @default.
- W2372009957 hasRelatedWork W2380857013 @default.
- W2372009957 hasRelatedWork W2390184147 @default.
- W2372009957 hasRelatedWork W2390607465 @default.
- W2372009957 hasRelatedWork W2391382628 @default.
- W2372009957 hasRelatedWork W2408862808 @default.
- W2372009957 isParatext "false" @default.
- W2372009957 isRetracted "false" @default.
- W2372009957 magId "2372009957" @default.
- W2372009957 workType "article" @default.