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- W2372018087 abstract "Objective: To evaluate the efficacy and toxicity of DDP combined with bimonthly 5 FU in the patients with nasopharyngeal carcinoma. Methods: The patients with a histologic diagnosis of NPC were eligible, including those who 1) had metastasis at presentation; 2) had developed metastatic disease after local radiotherapy; 3) had local advanced disease at presentation; 4) had local recurrent disease after radiotherapy. The chemotherapy regimen was comprised of bimonthly 2 hour infusion of leucovorin 200 mg/m2 followed by 10 minute intravenous bolus of 5 FU 375 mg/m2, then 48 hour infusion of 5 FU 3.0 g/m2 using an ambulatory pump plus high dose cisplatin 80 mg/m2 every 28 days with hydration in an outpatient setting. All enrolled patients were received at least two cycles of treatment. Results:Between December 1999 and April 2000,20 patients were enrolled into this study. After two cycles of chemotherapy,2 obtained complete remission(CR)(10%),12 obtained partial remission(PR)(60%), 6 had stable disease (SD) (30%),and no patients had progressive disease during treatment. Toxicity was comparatively mild. Phletitis,nausea,and vomiting were main side effects. No treatment related death occurred. Conclusion: Data from the current study indicated that bimonthly 5 FU/LV combined with DDP had moderate activity but comparatively mild toxicity for NPC patients who had locally advanced, recurrent or metastatic diseases." @default.
- W2372018087 created "2016-06-24" @default.
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- W2372018087 date "2001-01-01" @default.
- W2372018087 modified "2023-09-24" @default.
- W2372018087 title "Preliminary Report of Bimonthly 5-Fluorouracil(5-FU)/Leucovorin(LV)Combined with Cisplatin(DDP) in Nasopharyngeal Carcinoma" @default.
- W2372018087 hasPublicationYear "2001" @default.
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