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- W2372019988 abstract "AIM: To investigate whether the single nucleotide polymorphisms( SNPs) of interleukin-33( IL-33) gene are associated with inflammatory bowel disease( IBD) in the Han population of southern China. METHODS: Eight tag-SNPs were selected from the IL-33 gene using the HapMap database. These tag-SNPs were genotyped in 250 Crohn disease( CD) patients,115 ulcerative colitis( UC) cases and 622 healthy controls by MALDI-TOF MS assay. RESULTS: No difference of the distribution frequencies of genotypes and alleles between the cases and the controls was observed( P 0. 05). Genotype-phenotype analysis suggested that several sites were associated with clinical phenotypes of CD. The T allele of SNP rs10118795 was a protective factor for extra-intestinal manifestation( EIM; P 0. 05,OR = 0. 513,95% CI: 0. 281 ~ 0. 938),while the CC genotype of SNP rs7025417( P 0. 05,OR = 1. 363,95% CI: 1. 006 ~ 1. 846) was a risk factor for EIM. The C allele of rs10118795 decreased the risk for developing perianal lesions( P 0. 05, OR = 0. 480,95% CI: 0. 232 ~ 0. 994),while the CC genotype of rs10975519 was a risk factor for perianal lesions( P 0. 05,OR = 2. 054,95% CI: 1. 053 ~ 4. 009). The G allele of rs10975509 increased the risk of upper gastrointestinal CD( P 0. 05,OR =3. 570,95% CI: 1. 328 ~9.600),and the A allele of it increased the risk for developing ileocolonic CD( P 0. 05,OR = 0. 613,95% CI: 0. 377 ~ 0. 996). In the aspect of treatment,the genotypes of rs10118795, rs10975509 and rs7025417 were associated with mucosal healing after infliximab treatment for 30 weeks( P 0. 05,P 0. 01 and P 0. 05). In the UC patients,no significant effect of the selected 8 tag-SNPs on the UC phenotypes was observed. CONCLUSION: Eight polymorphisms of IL-33 do not increase the risk of CD and UC in the Han population of southern China,but some of them have an effect on the clinical phenotypes of CD,and 3 SNPs may be potential markers for prediction of effectiveness of infliximab treatment." @default.
- W2372019988 created "2016-06-24" @default.
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- W2372019988 date "2014-01-01" @default.
- W2372019988 modified "2023-09-23" @default.
- W2372019988 title "Genetic variants of IL-33 are associated with clinical phenotypes of inflammatory bowel disease in Han population of southern China" @default.
- W2372019988 hasPublicationYear "2014" @default.
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