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- W2372049391 abstract "Objective To investigate the effect of fosinopril on the expression of CX3C chemokine fractalkine and CD68 positive cells and its reno-protective mechanism in renal tissue of diabetic rats.Methods The rats were randomly divided into four groups,including normal control(NC group),nephrectomized rats(NE group),diabetic rats(DM group)and diabetic rats treated with fosinopril(DF group).Diabetes was induced by injection of streptozotocin after nephrectomy.Immunohistochemistry was used to examine the expression of fractalkine and CD68 positive cells.The mRNA of fractalkine was detected by RT PCR.Results After 8 weeks,fractalkine mRNA and protein expression in rat kidney of DM group were markedly increased as compared with that of NC group and NE group(P0.05).The increased expression was suppressed by the treatment with fosinopril.Increased infiltration of CD68 positive cells in diabetic glomeruli was also inhibited by the treatment(P0.05).The number of CD68 positive cells in glomeruli was positively correlated with the mRNA expression of fractalkine(r=0.807,P0.01).Conclusion Fractalkine up-regulation was demonstrated in diabetic kidney.The up-regulation,as well as CD68 positive cell infiltration,was suppressed by the treatment with fosinopril for 8 weeks.These findings suggest that fractalkine expression may play an important role in the inflammatory progression of diabetic nephropathy.Fosinopril may inhibit inflammation of diabetic nephropathy by suppressing the expression of fractalkine." @default.
- W2372049391 created "2016-06-24" @default.
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- W2372049391 date "2007-01-01" @default.
- W2372049391 modified "2023-09-27" @default.
- W2372049391 title "Effect of Fosinopril on the Expression of Fractalkine and CD68 Positive Cells in Diabetic Kidney Tissue in Rats" @default.
- W2372049391 hasPublicationYear "2007" @default.
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