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- W2372049562 abstract "Objective:To study the methylation status of three negative regulators for hedgehog pathway including growth arrest specific 1(GAS1),human hedgehog interacting protein(HHIP) and patched1(PTCH1),in order to investigate the value of them in the early diagnosis of stageⅠnon-small-cell lung cancer(NSCLC).Methods:A total of 85 patients with stageⅠNSCLC(NSCLC group) and 23 patients with non-cancerous lung diseases(control group) have been enrolled in this study.Methylation-specific polymerase chain reaction(MSP) was used to detect the methylation status of three genes in five lung cancer cell lines A549,NCI-H1299,NCI-H460,LTEP-a-2 and SPC-A-1,as well as in the cancer tissue samples from NSCLC group and lung lesions from control group.The sensitivity and specificity of three genes were analyzed when the methylation detection of each of them was applied for the diagnosis of stageⅠNSCLC.Results: Although in NCI-H1299,all of three genes presented unmethy-lation;in the other four lung cancer cell lines there were at least one to two genes presenting methylation.The methylation rates of GAS1,HHIP and PTCH1 in NSCLC group were higher than those in control group(P0.05).The sensitivity and specificity were 69.41 % and 69.57 % when the methylation of GAS1 was used for the diagnosis of stageⅠNSCLC,while they were 49.41 % and 82.61 % for HHIP,and 34.12 % and 100.0 % for PTCH1.Conclusions: PTCH1,HHIP and GAS1 have been found abnormally hypermethylated in the tumor tissues from stageⅠNSCLC patients,which suggests that the abnormal activation of hedgehog pathway may be involved in the genesis and development of NSCLC.Further study of the methylation status of these genes in the cell-free serum DNA from stageⅠNSCLC patients may provide novel methylation biomarkers for the diagnosis of NSCLC at early stages." @default.
- W2372049562 created "2016-06-24" @default.
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- W2372049562 date "2013-01-01" @default.
- W2372049562 modified "2023-09-27" @default.
- W2372049562 title "Methylation Status of Negative Regulators for Hedgehog Pathway in Early-Stage Non-Small-Cell Lung Cancer" @default.
- W2372049562 hasPublicationYear "2013" @default.
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