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- W2372054103 abstract "AIM To establish a rapid LC-MS/MS method for the determination of clopidogrel and its carboxylic acid metabolite(SR26334)in human plasma.METHODS The samples were extracted from plasma with aether-N-hexane(4:1,V:V)in acidity and neutral surroundings by twice liquid-liquid extraction. Chromatograph was carried out on a Teknokroma C_(18) column,using nateglinide and pioglitazone as internal standard,and the concentrations of clopidogrel and its carboxylic acid metabolite were determined simultaneously.The mobile phase was methyl alcohol-water with 0.1% formic acid(80:20,V:V).The flow rate was set on 0.2mL·min~(-1) and analyzed by mass spectrometry in the multiple reaction monitoring mode using the respective[M+H]~+ ions:m/z 322.1→212.1 for clopidogrel and m/z 318.3→166.2 for nateglinide,m/z 308.1→198.1 for carboxylic acid metabolite of clopidogrel and m/z 357.2→134.2 for pioglitazone.RESULTS The retention time of clopidogrel and internal standard nateglinide were approximately 4.4 min and 3.7 min, respectively.And the retention time of SR26334 and internal standard pioglitazone were 1.3 rain and 1.7 min, respectively.A good linearity was shown in the concentration range 5-5000ng·L~(-1) for clopidogrel,and the range 20-2 500μg·L~(-1) for SR26334.The extraction recovery was more than 75% and the method recovery was more than 90%.The interday or intraday precision was less than 10% in replicate analysis(n=5). CONCLUSION This method is simple and quick.It is suitable for clinical investigation and the therapeutic drug monitoring of clopidogrel." @default.
- W2372054103 created "2016-06-24" @default.
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- W2372054103 date "2008-01-01" @default.
- W2372054103 modified "2023-09-23" @default.
- W2372054103 title "Simultaneous determination of clopidogrel and its carboxylic acid metabolite in human plasma by liquid chromatography/tandem mass spectrometry" @default.
- W2372054103 hasPublicationYear "2008" @default.
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