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- W2372063616 abstract "Objective To establish a feasible and stable liver metastasis model of human colon cancer in nude mice. Observe of dovitinib(TKI-258) anti-tumor effect in liver metastasis model of human colon cancer. Methods Human colon cancer cell line Lo Vo were injected into spleen of nude mouse by ectopic implantation to establish the liver metastasis model of human colon cancer. The tumor-bearing nude mice were randomized into two groups,TKI-258 study group and control group. TKI-258 was force-fed(gavage) to study group and control group,evaluating tumor formation,growth efficiency and liver metastasis via morphological and histopathological examination. Results The tumor formation rate was100% of liver metastasis of colon cancer in nude mice by ectopic implantation. TKI-258 group inhibited the liver metastasis compared with the control group with a statistically significance(P 0. 05). There were marked morphological difference of liver metastasis between TKI-258 group and control group,which the liver metastasis of TKI-258 group was comparably narrowed,infiltration depth became shallowed with some cured scars(P 0. 05). In addition,the liver metastasis of TKI-258 group was microscopically distinct from the control group,on which exhibited irregularly distributed cells in the edge of the tumor with cell necrosis and apoptosis in the center(P 0. 05). Conclusion This liver metastasis model of human colon cancer facilitates the preclinical research and assessment requiring high rates of liver metastasis and liver tumor formation. Moreover,TKI-258 group may have certain curative effects on prevention and treatment for liver metastasis model of human colon cancer in nude mice by ectopic implantation,and may has significant restraining effect on the tumor formation,which remains clinical trials to confirm the quantitative effects." @default.
- W2372063616 created "2016-06-24" @default.
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- W2372063616 date "2014-01-01" @default.
- W2372063616 modified "2023-09-28" @default.
- W2372063616 title "Anti-tumor of the dovitinib on liver metastasis of colon cancer nude mice model" @default.
- W2372063616 hasPublicationYear "2014" @default.
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