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- W2372070516 abstract "Objective To investigate whether Trichostatin A (TSA) possesses anti-tumor activity against human breast cancer cells.Methods Human breast cancer cell line T47D was treated with differ- ent concentrations of TSA,a potent and specific histone deacetylase inhibitor for 0 to 5 days.The growth of T47D cells was observed by MTT assay before and after TSA treatment.The cell cycle of T47D cells was analyzed by flow cytometry.The expression of Maspin mRNA was detected by reverse transcription- polymerase chain reaction (RT-PCR).Results TSA significantly inhibited the proliferation of breast cancer cell in a dose-and time-dependent manner when the concentration was above 20μg/L.The inhibi- tion rate of 100μg/L TSA treatment was increased sharply from day 2 to 5 (46.17% to 73.01%).100μg/L TSA treatment could also induce cell cycle arrest at the G1 phase and increase apoptosis.Maspin mRNA was expressed in T47D cells after 100μg/L TSA treatment,but it was weakly detectable at 20μg/L TSA and control group.Conclusion TSA can inhibit breast cancer cell growth in vitro,possibly through G1 cell cycle arrest and induction of re-expression of Maspin gene.This study suggests that TSA may be a potential therapeutic agent for the treatment of breast cancer." @default.
- W2372070516 created "2016-06-24" @default.
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- W2372070516 date "2007-01-01" @default.
- W2372070516 modified "2023-09-23" @default.
- W2372070516 title "Molecular mechanisms of Trichostatin A inhibiting the proliferation of breast cancer cells" @default.
- W2372070516 hasPublicationYear "2007" @default.
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